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Large Volume Liposuction Improves Cholesterol Level and Diabetes

A recent systematic review was recently published evaluating whether large volume liposuction improves diabetes and decrease cholesterol levels. Large volume liposuction (defined as liposuction of more than 3.5 L) was found to decrease the total Body Mass Index (BMI), as well as improved cardiovascular risk factors by decreasing the cholesterol levels as well as improved insulin sensitivity.

Before & After Photos of VASER Liposuction performed by Dr. Emmanuel De La Cruz.

"A total of 364 patients were pooled for analysis. The mean volume of lipoaspirate was 7440 ± 1934.9 mL. The mean body mass index at baseline and postliposuction was 30.7 and 28.4, respectively. Seven studies reported a trend toward decrease in total cholesterol levels with an overall mean reduction of 0.21 ± 0.05 mmol/L from 4.6 ± 0.79 mmol/L to 4.4 ± 0.74 mmol/L. After LVL, leptin was reported to significantly decrease in 4 studies, and TNF-α was reported to significantly decrease in 2. Adiponectin was reported to significantly increase in 2 studies. IL-6 decreased significantly in 2 studies. Two studies included participants with type II diabetes mellitus, whereas 10 studies evaluated insulin sensitivity. Of these, 6 studies reported improvement in insulin sensitivity. Six studies represented level IV and 6 represented level II evidence."

Thus, large volume liposuction may be beneficial in terms of improving cardiovascular risk factors as well as improving diabetes by increasing insulin sensitivity.

Emmanuel De La Cruz MD, PLLC

Plastic & Reconstructive Surgeon


Sailon, et al. Influence of Large-Volume Liposuction on Metabolic and Cardiovascular Health: A Systematic Review. Annals of Plastic Surgery. 2017 Jul 22. doi: 10.1097/SAP.0000000000001195. [Epub ahead of print]

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